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The role of Cdc42 Rho GTPase in the cystic fibrosis intestinal epithelial barrier
(University of Missouri--Columbia, 2022)
dysfunction with intestinal barrier dysfunction are not well understood. Previously, we demonstrated that intracellular pH (pHi) is increased in Cftr KO mouse intestinal epithelium compared to wild-type (WT). Loss of Cftr-mediated Cl- and HCO3- conductance...
Evaluating the molecular drivers of physical inactivity and muscle atrophy as initiating factors in cognitive impairment
(University of Missouri--Columbia, 2023)
for brain glucose metabolism. The hindlimb immobilization (HLI) experiments found that inducing muscle atrophy through inactivity in female rats caused significant increases in hippocampal mitochondrial H2O2 emissions, signs of hippocampal insulin resistance...